Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase
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چکیده
منابع مشابه
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase.
BACKGROUND Citrullination catalysed by peptidylarginine deiminases (PADs) plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) and, possibly, several other inflammatory diseases. Non-physiological reducing agents such as dithiothreitol (DTT) are normally added to the reaction buffer when determining PAD activity in vitro. We investi...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2016
ISSN: 1478-6362
DOI: 10.1186/s13075-016-1000-7